Activation of Tgf-beta 2 in Association with Chondrocyte Apoptosis
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چکیده
During endochondral bone formation, chondrocytes pass through several distinct stages of differentiation, including cell division and hypertrophy. The terminal step in this process, chondrocyte apoptosis, is followed by vascular invasion and bone formation on cartilage remnants. Chondrocytes in culture have been shown to express and release high levels TGF-beta 2. We report here that the apoptosis of hypertrophic chondrocytes results in the activation of TGFbeta 2. This is associated with changes in the molecular organization of the TGFbeta 2 complex.
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